OSR-1 nucleic acids and proteins
OSR-1 nucleic acids and proteins
United States Patent 7,094,945
Solomon , et al.
August 22, 2006
Inventors: Solomon; Aaron (Evanston, IL), Morimoto; Richard (Evanston, IL), Beitel; Greg (Wilmette, IL)
Assignee: Northwestern University (Evanston, IL)
Appl. No.: 10/736,868
Filed: December 16, 2003
Abstract
The present invention relates to water-stress tolerance, in particular to the OSR-1 (osmotic stress resistant-1) protein, and nucleic acids encoding the OSR-1 protein. The present invention provides assays for the detection of OSR-1, and polymorphisms and mutations associated with water stress tolerance. In particular, the present invention relates to compositions comprising small interfering RNA duplexes (RNAi), or vectors that encode dsRNA, that inhibit expression of the OSR-1 gene (e.g. by targeting OSR-1 mRNA), and methods of using these compositions to impair deleterious nematodes.
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