Naphthalimide compositions and uses thereof
United States Patent Application 20050142214
Kind Code A1
Brown, Dennis M. June 30, 2005
Naphthalimide compositions and uses thereof
Abstract
A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a naphthalimide and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the naphthalimide comprises amonafide (5-amino-2-[2-(dimethylamine)ethyl]-1H-- benz[de-]isoquinoline-1,3-(2H)-dione). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes. The invention comprises the described methods as well as compositions comprising a naphthalimide and an antiproliferative agent.
Inventors: Brown, Dennis M.; (Menlo Park, CA)
Correspondence Name and Address: Richard F. Trecartin
Dorsey & Whitney LLP
Intellectual Property Department
Four Embarcadero Center, Suite 3400
San Franciso
CA
94111-4187
US

Assignee Name and Adress: ChemGenex Therapeutics, Inc.
Serial No.: 067074
Series Code: 11
Filed: February 25, 2005
U.S. Current Class: 424/649; 514/263.1; 514/269; 514/27; 514/283; 514/411; 514/44; 514/49; 514/568
U.S. Class at Publication: 424/649; 514/411; 514/044; 514/049; 514/027; 514/263.1; 514/269; 514/283; 514/568
Intern'l Class: A61K 031/403; A61K 048/00; A61K 031/7072; A61K 031/522; A61K 031/4745; A61K 031/7048
Comments: 0
Votes:20