NOVEL METHOD FOR OVERCOMING RNAi-RESISTANT STRAIN OF VIRUS - European Patents

NOVEL METHOD FOR OVERCOMING RNAi-RESISTANT STRAIN OF VIRUS
Publication number: WO2006090906
Publication date: 2006-08-31
Inventor: TAKAKU HIROSHI (JP); KUROSAKI NAOKO (JP); BARNOR JACOB SAMSON (JP)
Applicant: HAPLOPHARMA INC (JP); TAKAKU HIROSHI (JP); KUROSAKI NAOKO (JP); BARNOR JACOB SAMSON (JP)
Classification:
- international: C12N15/00; A61K31/7105; A61K35/76; A61K48/00; A61P31/12; A61P31/18; A61P35/00; C07H21/04; C12N15/00; A61K31/7105; A61K35/66; A61K48/00; A61P31/00; A61P35/00; C07H21/00;
- european:
Application number: WO2006JP304029 20060224
Priority number(s): JP20050051602 20050225

Cited documents:

JP9110894

Abstract of WO2006090906

A chimeric RNA molecule comprising at least one shRNA (short hairpin RNA) segment capable of forming siRNA which can act through viral RNA (target sequence) to inhibit the replication/growth of a virus or at least one miRNA segment capable of acting through viral RNA (target sequence) to inhibit the expression of a protein involved in the life cycle of the virus, and further comprising at least one RNA segment selected from the group consisting of: at least one decoy RNA segment capable of binding to a protein involved in the life cycle of the virus to inhibit the replication/growth of the virus; at least one antisense RNA segment capable of hybridizing to a gene involved in the life cycle of the virus to inhibit the replication/growth of the virus; an RNA segment comprising at least one ribozyme capable of inhibiting the expression of a protein involved in the life cycle of the virus; an RNA segment comprising at least one tRNase ZL-EGS capable of inhibiting the expression of a protein involved in the life cycle of the virus; and an RNA segment comprising at least one RNase P-EGS capable of inhibiting the expression of a protein involved in the life cycle of the virus, two or more of the RNA segments being cleavably linked to one another.