NON-POLAR PHOTOSENSITIZER FORMULATIONS FOR PHOTODYNAMIC THERAPY - European Patents

Patent number: WO2005023220
Publication date: 2005-03-17
Inventor: ALBRECHT VOLKER; FAHR ALFRED; SCHEGLMANN DIETRICH; GRAEFE SUSANNA; NEUBERGER WOLFGANG
Applicant: CERAMOPTEC IND INC (US)
Classification:
- international: A61K9/127
- european:
Application number: WO2004US20163 20040623
Priority number(s): US20030648168 20030826
Abstract of WO2005023220
A pharmaceutical liposomal formulation for photodynamic therapy comprising a non-polar porphyrin photosensitizer and one or more phospholipids, which are stable in storage without requiring freeze-drying is described. The liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. The phospholipids may be modified by pegylation, i.e. they contain poly ethylene glycol as an integral part of the phospholipids. The formed liposomes contain the non-polar photosensitizer within the membrane and are useful for the combined targeting of a nonpolar photosensitizer and a second polar substance. When a formulation includes the presence of monosaccharides or polyalcohols, it can be efficiently freeze-dried preserving the size of the liposomal vehicles and the content of a therapeutically effective amount of the photosensitizing agent. The invention also relates to the liposome composition formed upon reconstitution with an aqueous vehicle. The freeze-dried formulation upon reconstitution with a suitable aqueous vehicle forms liposomes that are also useful for intravenous administration.
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