Mhc class I peptide epitopes from the human 5t4 tumor-associated antigen - Patent Pending

United States Patent Application 20050123918
Kind Code A1
Carroll, Miles ; et al. June 9, 2005
Mhc class I peptide epitopes from the human 5t4 tumor-associated antigen
Abstract
There is provided an MHC class I peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the amino acid sequence shown as SEQ ID No.2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No.3; (iii) the minimal epitope from the amino acid sequence shown as SEQ ID No.4. (iv) the minimal epitope from the amino acid sequence shown as SEQ ID No. 5. (v) the minimal epitope from the amino acid sequence shown as SEQ ID No.6. (vi) the minimal epitope from the amino acid sequence shown as SEQ ID No.7. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease.
Inventors: Carroll, Miles; ( Oxford, GB) ; Kingsman, Susan; (Oxford, GB)
Correspondence Name and Address: TOWNSEND AND TOWNSEND AND CREW, LLP
TWO EMBARCADERO CENTER
EIGHTH FLOOR
SAN FRANCISCO
CA
94111-3834
US
Serial No.: 504602
Series Code: 10
Filed: August 12, 2004
PCT Filed: February 13, 2003
PCT NO: PCT/GB03/00670
U.S. Current Class: 435/6; 424/185.1; 435/320.1; 435/325; 435/372; 435/69.1; 530/350; 530/388.22; 536/23.5
U.S. Class at Publication: 435/006; 435/069.1; 435/320.1; 435/325; 530/350; 536/023.5; 424/185.1; 530/388.22; 435/372
Intern'l Class: C12Q 001/68; C07H 021/04; A61K 039/00; C07K 014/74; C07K 016/28