Methods of modulating pharmacokinetics of oligonucleotides

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Methods of modulating pharmacokinetics of oligonucleotides
Inventor: PRAKASH THAZHA P (US); MANOHARAN MUTHIAH (US)
Applicant: ISIS PHARMACEUTICALS INC (US)
EC: C07H19/06E; C12N15/11B
iPC: C07H19/06; C12N15/11; C07H19/00
Publication info: US6921812
Date: 2005-07-26
Abstract of US6921812
2'-O-(2-Methylthioethyl), has been incorporated into oligonucleotides and evaluated for antisense properties in comparison with the known 2'-O-(2-methoxyethyl) 2'-O-MOE modification. The 2'-O-MTE modified oligonucleotides exhibit improved binding to human serum albumin compared with the 2'-O-MOE modified oligonucleotides and maintain high binding affinity to target RNA.