Method of lyophylization to reduce solvent content and enhance product recovery

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United States Patent Application 20030068416
Kind Code A1
Burgess, Wilson ; et al. April 10, 2003
Abstract
The present invention relates to an improved method for lyophilization or freeze-drying. More specifically, the present invention relates to methods for reducing the residual solvent content of a material during lyophilization or freeze-drying by the addition of a compound effective therefor, such as ascorbic acid, or a suitable derivative thereof, such as a salt or ester thereof, or mannitol.
Inventors: Burgess, Wilson; (Clifton, VA) ; Drohan, William N.; (Springfield, VA) ; MacPhee, Martin J.; (Montgomery Village, MD) ; Mann, David M.; (Gaithersburg, MD) ; Beall, Dawson; (Gaithersburg, MD)
Correspondence Name and Address: FLESHNER & KIM, LLP
P.O. Box 221200
Chantilly
VA
20153-1200
US
Serial No.: 960705
Series Code: 09
Filed: September 24, 2001
U.S. Current Class: 426/384; 426/385; 514/474
U.S. Class at Publication: 426/384; 426/385; 514/474
Intern'l Class: A23C 001/06; A61K 031/375