Method of lyophylization to reduce solvent content and enhance product recovery

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Patent Number: US2003068416
Publication date: 2003-04-10
Inventor(s): BURGESS WILSON [US]; DROHAN WILLIAM N [US]; MACPHEE MARTIN J [US]; MANN DAVID M [US]; BEALL DAWSON [US]
Applicant(s):
Requested Patent: WO03026786
Application Number: US20010960705 20010924
Priority Number(s): US20010960705 20010924
IPC Classification: A23C1/06; A61K31/375
EC Classification: A01N1/02, F26B5/00B, F26B5/06
Equivalents:
Abstract
The present invention relates to an improved method for lyophilization or freeze-drying. More specifically, the present invention relates to methods for reducing the residual solvent content of a material during lyophilization or freeze-drying by the addition of a compound effective therefor, such as ascorbic acid, or a suitable derivative thereof, such as a salt or ester thereof, or mannitol.
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