Method of inducing a systemic immune response to an antigen

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Patent Number: US2004258746
Publication date: 2004-12-23
Inventor(s): SEE JACKIE R [US]; SEE DARRYL M [US]
Applicant(s): ORAL VACCINE TECHNOLOGIES INC [US]
Requested Patent: US2004258746
Application Number: US20040821691 20040408
Priority Number(s): US19980007297 19980114; US20020057484 20020125; WO1997US04634 19970324; US19990358962 19990722; US20000706083 20001103; US20040821691 20040408; US19970882968 19970626; US19970948568 19971010
IPC Classification: A61K39/00; A61K9/127
EC Classification: A61K9/127, A61K9/48Z, A61K39/21, A61K39/29
Equivalents:
Abstract
A method is provided for inducing a systemic immune response to an antigen. The method comprises providing a liposomal preparation comprising lyophilized liposomes containing at least one antigen. The liposomes have at least two sizes, before lyophilization, selected from small liposomes having a size, before lyophilization, of from about 20 nm to about 1 micron, medium liposomes having a size, before lyophilization, of from about 1 micron to about 3 microns, and large liposomes having a size, before lyophilization, of from about 3 microns to about 20 microns. An effective amount of the liposomal preparation is administered to a mammal, whereby sufficient antigen containing liposomes are absorbed in the Peyer's patches of the gut of the mammal and are taken up by macrophages in the Peyer's patches to stimulate a systemic immune response.
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