Method for improving stability and shelf-life of liposome complexes

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United States Patent Application 20050002998
Kind Code A1
Chang, Esther H. ; et al. January 6, 2005
Abstract
A method for preparing a stable cell-targeting complex comprising a ligand and a cationic liposome encapsulating a therapeutic or diagnostic agent comprises (a) combining the complex with a solution comprising a stabilizing amount of sucrose and (b) lyophilizing the resultant solution to obtain a lyophilized preparation; wherein, upon reconstitution, the preparation retains at least about 80% of its pre-lyophilization activity.
Inventors: Chang, Esther H.; (Potomac, MD) ; Pirollo, Kathleen F.; (Rockville, MD)
Correspondence Name and Address: ROTHWELL, FIGG, ERNST & MANBECK, P.C.
1425 K STREET, N.W.
SUITE 800
WASHINGTON
DC
20005
US
Assignee Name and Adress: Georgetown University
Washington
DC
Serial No.: 860640
Series Code: 10
Filed: June 4, 2004
U.S. Current Class: 424/450; 435/458
U.S. Class at Publication: 424/450; 435/458
Intern'l Class: A61K 009/127; C12N 015/88
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