Method for improving stability and shelf-life of liposome complexes
Patent Number: US2005002998
Publication date: 2005-01-06
Inventor(s): CHANG ESTHER H [US]; PIROLLO KATHLEEN F [US]
Applicant(s): UNIV GEORGETOWN [US]
Requested Patent: US2005002998
Application Number: US20040860640 20040604
Priority Number(s): US20030475500P 20030604; US20040860640 20040604
IPC Classification: A61K9/127; C12N15/88
EC Classification: A61K48/00D2, C12N15/88
Equivalents:
Abstract
A method for preparing a stable cell-targeting complex comprising a ligand and a cationic liposome encapsulating a therapeutic or diagnostic agent comprises (a) combining the complex with a solution comprising a stabilizing amount of sucrose and (b) lyophilizing the resultant solution to obtain a lyophilized preparation; wherein, upon reconstitution, the preparation retains at least about 80% of its pre-lyophilization activity.
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