Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein

Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein
United States Patent 7,045,306
Krainc
May 16, 2006
Inventors: Krainc; Dimitri (Boston, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Appl. No.: 425175
Filed: April 28, 2003
Abstract
The invention relates to methods and products for deregulating gene transcription in neurodegenerative disease associated with an expanded polyglutamine tract in mutant proteins. The invention is useful for preventing and treating diseases associated with expanded polyglutamine tracts, including Huntington's disease. The methods and compositions of the invention are also useful for identifying additional pharmaceutical agents for preventing and treating diseases associated with expanded polyglutamine tracts.
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