Method for freezing viable cells

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Patent Number: US2004191754
Publication date: 2004-09-30
Inventor(s): MEIR URI [IL]; AMSALEM YORAM [IL]; NATAN YEHUDIT [IL]; ARAV AMIR [IL]
Applicant(s):
Requested Patent: US2004191754
Application Number: US20040488414 20040302
Priority Number(s): WO2002IL00738 20020905; US20010317147P 20010906; US20020391575P 20020627; US20040488414 20040302
IPC Classification: A01N1/00; A01N1/02
Abstract
A method and a device for improved freezing of biological containing living cells is disclosed. Directional cooling coupled with agitation, preferably rotation, of the vessel containing the biological sample allows for the freezing of large volume samples at much grater rates than before. Whether a sample is large or not, the greater thermal homogeneity during the freezing process as well as the resulting crystal morphology yield a frozen sample which is exceptionally suited for lyophilization.

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