Method for freezing viable cells - Patent Pending

United States Patent Application 20040191754
Kind Code A1
Meir, Uri ; et al. September 30, 2004
Abstract
A method and a device for improved freezing of biological containing living cells is disclosed. Directional cooling coupled with agitation, preferably rotation, of the vessel containing the biological sample allows for the freezing of large volume samples at much grater rates than before. Whether a sample is large or not, the greater thermal homogeneity during the freezing process as well as the resulting crystal morphology yield a frozen sample which is exceptionally suited for lyophilization.
Inventors: Meir, Uri; (Kibbultz Bet Hashita, IL) ; Amsalem, Yoram; (Gan Yavneh, IL) ; Natan, Yehudit; (Holon, IL) ; Arav, Amir; (Tel Aviv, IL)
Correspondence Name and Address: NATH & ASSOCIATES
1030 15th STREET
6TH FLOOR
WASHINGTON
DC
20005
US
Serial No.: 488414
Series Code: 10
Filed: March 2, 2004
PCT Filed: September 5, 2002
PCT NO: PCT/IL02/00738
U.S. Current Class: 435/1.1; 435/284.1
U.S. Class at Publication: 435/001.1; 435/284.1
Intern'l Class: A01N 001/00; A01N 001/02
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