Means for stabilizing compositions and reagents thereof

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Patent Number: US2004180320
Publication date: 2004-09-16
Inventor(s): OKUDA MASAHIRO [JP]; HIURA HISAHIDE [JP]
Applicant(s):
Requested Patent: US2004180320
Application Number: US20040769937 20040202
Priority Number(s): JP19990366663 19991224; US20020168756 20020618; US20040769937 20040202
IPC Classification: A01N1/02
EC Classification: G01N33/52, G01N33/86
Abstract
A means for stable preparing a composition, which comprises plasma component derived from human or animals, at least fibrinogen, which is blood coagulation factor, and factor V, is provided, and the composition prepared remains stable even when allowed to stand over one day or longer in a freeze-dried state, in freeze-thawed state, in a refrigerator, or under room temperature. By adding an inhibitor of Factor XIII in an effective amount for achieving the inhibitory effect, compositions comprising human or animal plasma components, at least fibrinogen and Factor V, which are blood coagulation factors, and reagents for measuring extrinsic coagulation factor for blood coagulation function comprising at least thromboplastin, Factor V and fibrinogen can be stabilized during preparation, storage and measurement.

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