Marek's disease virus genes and their use in vaccines for protection against marek's disease - Patent Pending

United States Patent Application 20020085999
Kind Code A1
Lee, Lucy F. ; et al. July 4, 2002
Marek's disease virus genes and their use in vaccines for protection against marek's disease
Abstract
A nucleotide sequence encoding the gp82 polypeptide of Marek's disease virus is disclosed. Also disclosed are recombinant viruses which are useful as vaccines for protecting against Marek's Disease, preferably containing two more genes encoding Marek's Disease Virus antigens such as glyprotein B and glycoprotein gp82, under the control of a poxvirus promoter within a region of the DNA of fowlpox virus which is not essential for virus growth. Also provided is a vaccine exhibiting a synergistic immunoprotective effect, comprising a recombinant fowlpox virus expressing Marek's Disease Virus gB protein in combination with turkey herpesvirus. A method of immunizing poultry, comprising administering any of the disclosed vaccines, is also provided.
Inventors: Lee, Lucy F.; (East Lansing, MI) ; Nazerian, Keyvan; (Skokie, IL) ; Witter, Richard L.; (Okemos, MI) ; Wu, Ping; (East Lansing, MI) ; Yanagida, Noboru; (Nakahara-ku, JP) ; Yoshida, Shigeto; (Kamakura-shi, JP)
Correspondence Name and Address: BIRCH STEWART KOLASCH & BIRCH
PO BOX 747
FALLS CHURCH
VA
22040-0747
US
Assignee Name and Adress: The USA, Secretary of Agriculture and Nippon Zeon Co., Ltd.
Serial No.: 920848
Series Code: 09
Filed: August 3, 2001
U.S. Current Class: 424/93.21; 435/235.1; 435/320.1; 536/23.2
U.S. Class at Publication: 424/93.21; 435/235.1; 435/320.1; 536/23.2
Intern'l Class: A61K 048/00; C07H 021/04; C12N 015/863; C12N 007/00