METHODS FOR PRODUCING, GROWING, AND PRESERVING LISTERIA VACCINE VECTORS

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METHODS FOR PRODUCING, GROWING, AND PRESERVING LISTERIA VACCINE VECTORS
Publication Number: WO/2007/061848 International Application No.: PCT/US2006/044681
Publication Date: 31.05.2007 International Filing Date: 16.11.2006

Int. Class.: C12N 1/20 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 CHESTNUT STREET-SUITE 200, Philadelphia, PA 19104-6283 (US) (All Except US).
ADVAXIS [US/US]; THE TECHNOLOGY CENTER OF NEW JERSEY, 675 U.S. ROUTE 1, SUITE 117, North Brunswick, NJ 08902 (US) (All Except US).
ROTHMAN, John [US/US]; 77 BISSELL ROAD, Labanon, NJ 08833 (US) (US Only).
PATERSON, Yvonne [US/US]; 514 SOUTH 46TH STREET, Philadelphia, PA 19143 (US) (US Only).
VERCH, Thorsten [DK/US]; 123 GWYNMOND CIRCLE, North Wales, PA 19545 (US) (US Only).
WEISS, Amanda [GB/GB]; 11 DIG LANE, Wybunbury, Nantwich XX CW5 7EZ (GB) (US Only).
BASSETT, Philip [GB/GB]; 27 BUCKMASTER AVENUE, CLAYTON, NEWCASTLE-UNDER-LYME, Staffordshire XX ST5 3AL (GB) (US Only).
Inventors: ROTHMAN, John [US/US]; 77 BISSELL ROAD, Labanon, NJ 08833 (US).
PATERSON, Yvonne [US/US]; 514 SOUTH 46TH STREET, Philadelphia, PA 19143 (US).
VERCH, Thorsten [DK/US]; 123 GWYNMOND CIRCLE, North Wales, PA 19545 (US).
WEISS, Amanda [GB/GB]; 11 DIG LANE, Wybunbury, Nantwich XX CW5 7EZ (GB).
BASSETT, Philip [GB/GB]; 27 BUCKMASTER AVENUE, CLAYTON, NEWCASTLE-UNDER-LYME, Staffordshire XX ST5 3AL (GB).
Agent: COHEN, Mark, S.; PEARL COHEN ZEDEK LATZER, LLP, 1500 Broadway, 12th Floor, New York, NY 10036 (US).
Priority Data: 60/737,419 17.11.2005 US
60/758,194 12.01.2006 US

Abstract: The present invention provides methods for cryopreservation and lyophilization of a Listeria strain, methods for producing a cell bank or a batch of vaccine doses of same, methods of characterizing same, and defined microbiological media.