METHOD OF PYROGENAL PRODUCING

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Patent number: RU2168334
Publication date: 2001-06-10
Inventor: MALOFEEVA T P; KOLESNIKOVA V A; BUDNITSKAJA P Z
Applicant: PRED PROIZV BAKPREPARATOV NI S;; ROBIOLOGII IM N F GAMALEI RAMN
Classification:
- international: A61K31/739; A61K35/66
- european:
Application number: RU20000102786 20000208
Priority number(s): RU20000102786 20000208
Abstract of RU2168334

medicine, pharmaceutical industry, microbiology, biotechnology. SUBSTANCE: method of pyrogenal producing involves culturing bacterial mass of cultures Salmonella typhose and Pseudomonas aeruginosa, enzymatic hydrolysis, precipitate separation, hydrolyzate concentration, by-stage treatment of the end product with organic solvent followed by drying. Culturing is carried out for 12-15 h with addition of growth factors, formal in is added to its final concentration 0.2%, keeping at least for 3 h, hydrolyzate is concentrated by lyophilization. Obtained preparation has, %: carbohydrates, 40 +- 10; protein, 3, not above; nucleic acids, 5, not above. EFFECT: safety of process, simplified technology, standardization of produced preparation. 1 ex
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