METHOD OF PRODUCING A LYOPHILIZED LIPOSOME PRODUCT

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(12) Patent Application: (11) CA 2199018
ABSTRACT:
A method of forming a lyophilized liposome product by combining a lipid with an aqueous solution containing a drying protectant, without adding organic solvent, agitating the mixture to form a population of liposomes and then lyophilizing the mixture to form a lyophilized liposome product. The invention is also directed to the lyophilized products obtained by the method, and to liposomes prepared by reconstituting the lyophilized product. The lyophilization step may be carried out at higher drying temperatures resulting in, inter alia, a more cost effective process.
(72) Inventors (Country): EDGERLY-PFLUG, LAURA M. (United States)
COE, ROYDEN M. (United States)
(73) Owners (Country): THE LIPOSOME COMPANY, INC. (United States)
(71) Applicants (Country): THE LIPOSOME COMPANY, INC. (United States)
(74) Agent: OSLER, HOSKIN & HARCOURT LLP
(45) Issued:
(86) PCT Filing Date: Sep. 23, 1994
(87) PCT Publication Date: Mar. 28, 1996
(51) International Class (IPC): B01J 13/04
A61K 9/127
Patent Cooperation Treaty (PCT): Yes (85) National Entry: Mar. 3 , 1997
(86) PCT Filing number: PCT/US1994/010812
(87) International publication number: WO1996/009037
(30) Application priority data: None
Availability of licence: N/A
Language of filing: English