METHOD FOR IMPROVING STABILITY AND SHELF-LIFE OF LIPOSOME COMPLEXES

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Patent Number: WO2005000271
Publication date: 2005-01-06
Inventor(s): CHANG ESTHER H [US]; PIROLLO KATHLEEN F [US]
Applicant(s): UNIV GEORGETOWN [US];; CHANG ESTHER H [US];; PIROLLO KATHLEEN F [US]
Requested Patent: WO2005000271
Application Number: WO2004US17695 20040604
Priority Number(s): US20030475500P 20030604
IPC Classification: A61K9/127
EC Classification: A61K48/00D2, C12N15/88
Equivalents:
Cited Documents: US6372250; US4857319; US5753262; US5612057
Abstract
A method for preparing a stable cell-targeting complex comprising a ligand and a cationic liposome encapsulating a therapeutic or diagnostic agent comprises (a) combining the complex with a solution comprising a stabilizing amount of sucrose and (b) lyophilizing the resultant solution to obtain a lyophilized preparation; wherein, upon reconstitution, the preparation retains at least about 80% of its pre-lyophilization activity.

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