METHOD FOR CAREFULLY PRODUCING ULTRAFINE PARTICLE SUSPENSIONS AND ULTRAFINE PARTICLES AND USE THEREOF

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METHOD FOR CAREFULLY PRODUCING ULTRAFINE PARTICLE SUSPENSIONS AND ULTRAFINE PARTICLES AND USE THEREOF
Publication Number: WO/2006/108637 International Application No.: PCT/EP2006/003377
Publication Date: 19.10.2006 International Filing Date: 12.04.2006

Int. Class.: A61K 9/14 (2006.01), A61K 9/10 (2006.01), A61K 9/51 (2006.01)
Applicants: PHARMASOL GMBH [DE/DE]; Blohmstrasse 66a, 12307 Berlin (DE) (All Except US).
M?SCHWITZER, Jan [DE/DE]; Alt-Lankwitz 40B, 12247 Berlin (DE) (US Only).
LEMKE, Andreas [DE/DE]; S?htstrasse 9, 12203 Berlin (DE) (US Only).
Inventors: M?SCHWITZER, Jan [DE/DE]; Alt-Lankwitz 40B, 12247 Berlin (DE).
LEMKE, Andreas [DE/DE]; S?htstrasse 9, 12203 Berlin (DE).
Agent: VAN HEESCH, Helmut; Uexk?ll & Stolberg, Beselerstr. 4, 22607 Hamburg (DE).
Priority Data: 10 2005 017 777.8 13.04.2005 DE
10 2005 053 462.7 05.11.2005 DE
Abstract:
(EN) The invention relates to a multistage process in order to produce, in a very effective and careful manner, particles having an average particle size of 50 nm to 1000 nm, during which the solid substance (active substance) is dissolved in a solvent, and this liquid containing the solid substance (active substance) in dissolved form is then rapidly frozen. The solvent(s) used are removed from the obtained frozen matrix optionally during a (freeze)-drying process (lyophilization) or the frozen matrix is subjected to a direct subsequent processing. The solid matrix is dispersed in an outer phase and the resulting dispersion is then immediately subjected to high shear and/or cavitation forces. The forces used lead to a stabilization or reduction in size of the resulting particles on the nanometric scale.