Lyotherm 2 - Electrical Impedance (Zsin) and DTA Apparatus

Lyotherm 2 - Electrical Impedance (Zsin) and DTA Apparatus
By: Biopharma Technology Limited
Product Description:
Lyotherm 2 provides an integrated Differential Thermal Analyser (DTA) and newly-developed electrical impedance (Zsin) capability within one instrument. Lyotherm 2 has been designed to measure glass transition (Tg?), eutectic (Teu) and melting (Tm) temperatures relevant to freeze-drying formulations.
Building on the conventional ?electrical resistance? analysis that has traditionally been used for identification of softening or eutectic melting points in frozen materials, the use of impedance analysis ? and specifically the measurement of a derivative of impedance known as ?Zsin? - can provide important information as to the behaviour of the frozen solute phase1 which may not be identifiable using conventional analytical techniques. As a result of its unique design features, Lyotherm 2 not only has the benefit of combining DTA and Zsin analysis within one instrument, but also comes in at a fraction of the cost of many DSCs.
1L. Rey (1999) Glimpses into the Realm of Freeze-Drying: Classical Issues and New Ventures, In: Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products, L. Rey & J. May (eds), Marcel Dekker Inc., pp. 1-30
Lyotherm 2 and Lyostat 2 together provide valuable information that can be fed back into both formulation and cycle development processes. In addition, BTL has more innovative analytical instruments in the development pipeline.
PDF Brochure is available online.
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