Lyopohilization method

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Patent Number: US6684524
Publication date: 2004-02-03
Inventor(s): SENNHENN BERND [DE]; KRAMER MARTIN [DE]
Applicant(s): BAYER AG [DE]
Requested Patent: US6684524
Application Number: US20020048783 20020201
Priority Number(s): DE19991036281 19990802; WO2000EP07034 20000721
IPC Classification: F26B5/06
EC Classification: F26B5/06
Equivalents: AU6697200, CA2380949, DE19936281, EP1206670 (WO0109559), B1, JP2003506654T, WO0109559
Abstract
The invention relates to a lyophilization method which comprises the following steps: reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation; reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in a frozen solvent; and sublimation of the frozen solvent by means of reduced pressure.
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