Lyophilization method and apparatus for producing particles - Garbage

Lyophilization method and apparatus for producing particles
Inventor: SHEKUNOV BORIS Y (US); CHATTOPADHYAY PRATIBHASH (US)
Applicant: FERRO CORP (US)
EC: A61K9/16H4B; A61K9/16P4
IPC: A61K9/16; A61K9/19; F25D3/10
Publication info: US2005178020
Date: 2005-08-18
Abstract of US2005178020
A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.