LYOPHILIZED PHARMACEUTICAL PREPARATIONS CAPABLE OF PROVIDING AQUEOUS DRUG COMPOSITION HAVING PROPERTY OF REVERSIBLE THERMOSETTING GELATION

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(12) Patent: (11) CA 2202520
ABSTRACT:
Herein disclosed is a lyophilized pharmaceutical preparation obtained by lyophilizing an aqueous composition having property of reversible thermosetting gelation and comprising an effective amount of a drug, 0.2 to 2.1 (W/V)% of methylcellulose (the content of methoxyl group is within the range of 26 to 33%), 1.2 to 2.3 (W/V)% of citric acid and 0.5 to 13- (W/V)% of polyethylene glycol. The lyophilized pharmaceutical preparation makes it possible to stably store drugs unstable to water till they are put into practical use and, upon therapeutic use, an aqueous composition having property of reversible thermosetting gelation which can undergo gelation when locally applied can easily and immediately be reconstituted from the preparation by addition of a proper amount of a solvent for reconstitution.
(72) Inventors (Country): NAITO, KEIKO (Japan)
SASAKI, MIYAKO (Japan)
TAKEUCHI, MASANOBU (Japan)
SUZUKI, HIROE (Japan)
MARUYAMA, HIROKI (Japan)
OGUMA, TOURU (Japan)
MAEDA, MAKOTO (Japan)
TAKAHASHI, TOSHIE (Japan)

(73) Owners (Country): WAKAMOTO PHARMACEUTICAL CO., LTD. (Japan)
(71) Applicants (Country): WAKAMOTO PHARMACEUTICAL CO., LTD. (Japan)
(74) Agent: OGILVY RENAULT
(45) Issued: Sep. 5 , 2000
(86) PCT Filing Date: Oct. 13, 1994
(87) PCT Publication Date: Apr. 25, 1996
Examination requested: Apr. 11, 1997
(51) International Class (IPC): A61K 9/06
A61K 9/19
A61K 47/38
Patent Cooperation Treaty (PCT): Yes (85) National Entry: Apr. 11, 1997
(86) PCT Filing number: PCT/JP1994/001709
(87) International publication number: WO1996/011672
(30) Application priority data: None
Availability of licence: N/A
Language of filing: English