LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY
LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY
Publication Number: WO/2007/061529 International Application No.: PCT/US2006/040197
Publication Date: 31.05.2007 International Filing Date: 13.10.2006
Int. Class.: A61K 9/14 (2006.01)
Applicant: SCIDOSE PHARMA INC. [US/US]; 123 Blackberry Lane, Amherst, MA 01002 (US) (All Except US).
Inventor: PALEPU, Nageswara; 30 Addis Drive, South Hampton, PA 18966 (US).
Agent: FISHMAN, Irving, M.; Cohen Tauber Spievack Wagner, 420 Lexington Avenue, Suite 2400, New York, NY 10170 (US).
Priority Data: 11/282,507 18.11.2005 US
Abstract: A lyophilization process which comprises dissolving a material in one or more solvents for said material to form a solution; forcing said material at least partially out of solution by combining the solution and a non-solvent for the material, which non-solvent is miscible with the solvent or solvents used and wherein said non-solvent is volatilizable under freeze-drying conditions. In addition, for hydrophobic and/or lipophilic materials, the anti-solvent can be omitted, and the solution of the material in the solvent can be subjected directly to freeze drying. The lyophilizates can then be reconstituted with typical aqueous diluent in the case of hydrophilic materials. Hydrophobic and or lipophilic materials can be initially reconstituted with propylene glycol and/or polyethyleneglycol to form a high concentration solution therein and this is further diluted for use with a diluent of Intralipid, plasma, serum, or even whole blood.
Votes:14
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