Ionically formulated biomolecule microcarriers - Patent Articles

United States Patent 6,645,525
Woiszwillo November 11, 2003
Ionically formulated biomolecule microcarriers
Abstract
Compositions for sustained delivery of a biomolecule including an anionic polymer and a cationic polymer which ironically interact with each other and, optionally, with the biomolecule. Methods for making the compositions, including the step of combining the negatively charged polymer with the positively charged polymer to form an ionic complex are also provided. The biomolecule may be complexed with one of the polymers before it is complexed with the oppositely charged polymer. The complex is exposed to conditions that cause the formation of precipitated microcarriers, such as a change in pH or the addition of a complexing molecule. The compositions are preferably formulated into microcarriers.
Inventors: Woiszwillo; James E. (Milford, MA)
Assignee: Sedum Laboratories, Inc. (Mansfield, MA)
Appl. No.: 018991
Filed: May 6, 2002
PCT Filed: June 23, 2000
PCT NO: PCT/US00/17223
PCT PUB.NO.: WO01/01964
PCT PUB. Date: January 11, 2001
Current U.S. Class: 424/460; 264/4.1; 264/4.3; 264/4.4; 264/4.7; 424/184.1; 424/193.1; 424/457; 424/461; 424/489; 424/493; 424/497; 424/499; 428/402.21; 428/402.24; 514/2; 514/54; 514/951; 514/963; 525/54.2; 525/54.3; 525/535; 525/539; 525/540
Intern'l Class: A61K 009/64; A01N 037/18; B32B 015/02
Field of Search: 525/54.2,54.3,535,539,540 428/402.21,402.24 424/457,460,489,461,493,497,499,184.1,193.1,963 264/4.1,4.3,4.4,4.7 514/951,963,2,54