Inhibitors of integrin avb6 - Patent Pending

United States Patent Application 20050153902
Kind Code A1
Staehle, Wolfgang ; et al. July 14, 2005
Inhibitors of integrin avb6
Abstract
Novel biphenyl derivatives of the general formula I in which R.sub.1, R.sub.1', R.sub.1", R.sub.2, R.sub.2', R3 and n are as defined in Patent claim 1, stereoisomers thereof and physiologically acceptable salts or solvates thereof are novel integrin inhibitors which preferentially inhibit the .alpha.v.beta.6 integrin receptor. The novel compounds can be used, in particular, as medicaments. 1
Inventors: Staehle, Wolfgang; (Jugenheim, DE) ; Schadt, Oliver; (Oliver, DE) ; Jonczyk, Alfred; (Darmstadt, DE) ; Goodman, Simon; (Griesheim, DE)
Correspondence Name and Address: MILLEN, WHITE, ZELANO & BRANIGAN, P.C.
2200 CLARENDON BLVD.
SUITE 1400
ARLINGTON
VA
22201
US

Serial No.: 503616
Series Code: 10
Filed: August 5, 2004
PCT Filed: January 15, 2003
PCT NO: PCT/EP03/00327
U.S. Current Class: 514/19; 546/309
U.S. Class at Publication: 514/019; 546/309
Intern'l Class: A61K 038/04; C07D 213/72