IMPROVING AND PROTECTING CELL THERAPY FOR NEUROLOGICAL DISORDERS INCLUDING PARKINSON'S DISEASE
IMPROVING AND PROTECTING CELL THERAPY FOR NEUROLOGICAL DISORDERS INCLUDING PARKINSON'S DISEASE
Publication number: WO2006083797
Publication date: 2006-08-10
Inventor: ABELIOVICH ASA (US); MARTINAT CECILE (US)
Applicant: NEW YORK THE TRUSTEES OF COLUM (US); ABELIOVICH ASA (US); MARTINAT CECILE (US)
Classification:
- international: A61K48/00; C12N5/08; A61K48/00; C12N5/08;
- european:
Application number: WO2006US03295 20060131
Priority number(s): US20050048391 20050131
Abstract of WO2006083797
The present invention provides compositions and methods for enhancing and improving cell therapies for neurological disorders including Parkinson's disease. Specifically, the present invention provides a cell or cells modified by viral vector compositions that allow for the over-expression and RNAi mediated knockdown of genes in vitro and in vivo. The present invention further provides cell therapy methods for treating or preventing neurodegeneration in a subject, and for protecting neurons from damage in the context of neurodegenerative disorders using the modified cells. Additionally, the present invention provides methods for purification and identification of mature dopamine neurons for cell therapy using fluorescent compounds including JHCl-64.
Votes:17
Comments: 0