Hybrids of M. tuberculosis antigens

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United States Patent Application 20020176867
Kind Code A1
Andersen, Peter ; et al. November 28, 2002
Hybrids of M. tuberculosis antigens
Abstract
The present invention discloses fusion proteins of the immunodominant antigens ESAT-6 and Ag85B from Mycobacterium tuberculosis or homologues thereof, and a tuberculosis vaccine based on the fusion proteins, which vaccine induces efficient immunological memory.
Inventors: Andersen, Peter; (Bronshoj, DK) ; Olsen, Anja Weinreich; (Soborg, DK) ; Skjot, Rikke Louise Vinther; (Hedehusene, DK) ; Rasmussen, Peter Birk; (Frederiksberg, DK)
Correspondence Name and Address: Thomas J. Kowalski
c/o FROMMER LAWRENCE & HAUG LLP
745 Fifth Avenue
New York
NY
10151
US
Serial No.: 805427
Series Code: 09
Filed: March 13, 2001
U.S. Current Class: 424/190.1; 530/359
U.S. Class at Publication: 424/190.1; 530/359
Intern'l Class: A61K 039/04; C07K 014/30