Guanidine and amidine derivatives as factor Xa inhibitors
United States Patent Application 20050143419
Kind Code A1
Peyman, Anuschirwan ; et al. June 30, 2005
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Guanidine and amidine derivatives as factor Xa inhibitors
Abstract
The present invention relates to compounds of the formula I, 1 in which R.sub.0; Q; X; Q', D, R.sub.10 and V have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Inventors: Peyman, Anuschirwan; (Kelkheim, DE) ; Will, David William; (Kriftel, DE) ; Gerlach, Uwe; (Hattersheim, DE) ; Nazare, Marc; (Eppstein, DE) ; Zoller, Gerhard; (Schoneck, DE) ; Nestler, Hans-Peter; (Kelkheim, DE) ; Matter, Hans; (Langenselbold, DE) ; Al-Obeidi, Fahad; (Tucson, AZ)
Correspondence Name and Address: ROSS J. OEHLER
AVENTIS PHARMACEUTICALS INC.
ROUTE 202-206
MAIL CODE: D303A
BRIDGEWATER
NJ
08807
US
Assignee Name and Adress: Aventis Pharma Deutschland GmbH
Frankfurt am Main
DE
Serial No.: 886312
Series Code: 10
Filed: July 7, 2004
U.S. Current Class: 514/318; 514/326; 514/340; 514/364; 546/194; 546/209; 546/269.1; 548/132
U.S. Class at Publication: 514/318; 514/340; 514/326; 514/364; 546/209; 546/194; 546/269.1; 548/132
Intern'l Class: C07D 413/02; A61K 031/4545; A61K 031/454; A61K 031/4439; A61K 031/4245
Comments: 0
Votes:23