Genzyme Pharmaceuticals
Genzyme Pharmaceuticals
Who We Are
In 1982 a significant acquisition in the United Kingdom added to Genzyme's product line and manufacturing facilities. Koch Light Laboratories, a maker of industrial fine chemicals and reagents in Haverhill, Suffolk, became Genzyme Fine Chemicals. Four years later when its focus shifted to pharmaceuticals, it was renamed Genzyme Pharmaceuticals.
In 1994 Genzyme acquired Sygena AG, a Swiss facility focused on the production of high quality chemical intermediates and active pharmaceutical ingredients. The acquisition of the Sygena facility brought with it extensive peptide and amino acid derivative manufacturing capacity and capability while adding strength to an existing lipid development and manufacturing business.
Having undertaken numerous facility-wide upgrades and significant expansion over the past eight years, our Swiss facility has become the cornerstone of production and R&D for the Pharmaceuticals Division. In 1999, to better reflect our unified vision and the seamless working relationship between our Swiss operations and our corporate offices in the United States, Sygena officially changed its name to Genzyme Pharmaceuticals. This facility located in Liestal, 15 km from Basel , holds a current GMP certificate and has been inspected by the Swiss Regulatory Agency, the US FDA, numerous customers and Genzyme Corporate Quality Compliance. To date these inspections have resulted in no reported critical observations.
Our Swiss scientists have state-of-the-art systems and equipment and extensive experience with a broad array of reaction types. In addition to manufacturing production-scale quantities of a variety of active pharmaceutical ingredients and critical excipients, Genzyme Pharmaceuticals is working closely with some of the worlds leading drug companies to develop and supply the next generation of pharmaceuticals and drug delivery technologies to help satisfy unmet medical needs worldwide.
CONTACT INFORMATION:
Genzyme Pharmaceuticals
AMERICAS:
Genzyme Pharmaceuticals
675 West Kendall Street
Cambridge, MA 02142
USA
Tel: 617-374-7248
Fax: 617-768-6433
Corporate
Tel: 617-252-7500
Customer Service
Toll Free: 800-868-8208 (US / Canada)
Fax: 617-768-9765
REST OF WORLD:
Genzyme Pharmaceuticals
Eichenweg 1
Ch - 4410 Liestal
Tel: +41-(0)61-906-5959
Fax: +41-(0)61-906-5958
Contract Manufacturing
A successful drug development program requires a smooth transition from drug discovery, through scale-up to full-scale manufacturing. Genzyme Pharmaceuticals is the ideal partner to help enact this transition.
Genzyme Pharmaceuticals is a proven source for the contracted manufacture of your active pharmaceutical ingredient, advanced intermediate or critical excipients. Our FDA inspected facility in Liestal, Switzerland employs a streamlined project management system that ensures timely progression from route selection through scale-up to routine full-scale manufacture.
The facility incorporates state-of-the-art equipment with a logistical design that facilitates proper raw material receipt and storage as well as optimal product flow and handling. Independent quality management systems, supported by Genzyme Corporate Quality management Systems worldwide, enable us to provide reliable analytical testing, quality assurance and regulatory support that meets current registration requirements.
Our facility holds a current GMP certificate and has been inspected by the Swiss Regulatory Agency, the US FDA, numerous customers and Genzyme Corporate Quality Compliance. To date these inspections have resulted in no reported critical observations.
The facility maintains QA and QC laboratories fully integrated within Genzyme Corporate Quality. These labs are staffed with highly trained technicians and outfitted with state-of-the-art equipment helping to ensure that the customer receives seamless support in critical development areas.
Our facility is outfitted with ideal lab-scale equipment that mimics production-scale reactor conditions. All process development is done with scale-up in mind and as the scale of your project increases, we have the capacity to satisfy your manufacturing requirements all the way to the market.
From feasibility studies through Process Development, QA, QC, Analytical Support and ultimately to the commercially enabling production of your drug, Genzyme Pharmaceuticals is equipped with the capacity, experience and know-how to bring your product concept to the market.
Regardless of what phase your drug development program is in, contact Genzyme Pharmaceuticals today and find out how the Genzyme advantage can work for you.
Drug Delivery Technology
Almost all chemicals currently used as drug delivery excipients were originally developed for use in the textile, adhesives, construction, electronics, and polymer industries. Attempting to exploit the drug delivery potential of these materials, formulators find they often fail to provide the specialized delivery of today's pharmaceuticals that they require.
Just as the pharmaceutical industry applies systematic research and development to create breakthrough new chemical entities, Genzyme has created new classes of chemical compounds that have been optimized to achieve specific drug delivery goals. Working together with academic collaborators, we have capitalized on our expertise in the field of lipid development and offer the following novel patented drug delivery systems.
LipoBridge? delivers therapeutic quantities of small molecules, proteins, or antibody drugs across the blood-brain-barrier and into the central nervous system. As LipoBridge delivers drugs across tight junctions it can also facilitate drug transport across other membrane systems.
LipoMask? increases the circulation time of your lipid particle delivery system, improving drug efficacy and safety while allowing for targeting of the lipid particle.
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