Freeze-dried pharmaceutical preparation
Patent number: CN1571666
Publication date: 2005-01-26
Inventor: KIMIHIRO MIZUNO (JP)
Applicant: SUMITOMO PHARMA (JP)
Classification:
- international: A61K31/282; A61K9/19; A61P35/00
- european:
Application number: CN20020818527 20020919
Priority number(s): JP20010290265 20010921
Abstract not available for CN1571666
Abstract of correspondent: EP1447084
For clinical application of cis?((1R,2R)-1,2-cyclohexanediamine-N,N')bis(R<1>)?platinum(II) (R<1> is an alkanoyloxy 'group having 6 to 20 carbon atoms), the present invention aims at providing a formulation which prevents layer separation and changes in viscosity, shows fine suspendability, and which is easy to handle during administration. The formulation of the present invention is a lyophilized formulation for injection obtained by dissolving a cis?((1R,2R)-1,2-cyclohexanediamine-N,N')bis(R<1>)?platinum(II) in 2-methyl-2-propanol and lyophilizing this solution, which has a central particle size distribution of around 3 - 25 mu m and a D90% value of not more than 40 mu m.
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