Formulations for protection of peg-interferon alpha conjugates

/Home/Lyophilization and Protein Formulation Patents/Patent Articles - Lyophilization/European Patents - Lyophilization

Patent Number: US6250469
Publication date: 2001-06-26
Inventor(s): KLINE DOUGLAS [US]
Applicant(s): SCHERING CORP [US]
Requested Patent: US6250469
Application Number: US20000703581 20001101
Priority Number(s): US20000703581 20001101; US19980079471P 19980326; US19990268423 19990312
IPC Classification: B65D69/00; B65D71/00; A61K38/19; A61K38/21
EC Classification: A61K38/21A, A61K47/02, A61K47/26
Abstract
The present invention provides formulations that prevent loss and damage of PEG-interferon alpha conjugates during and following lyophilization. The formulations of the present invention protect PEG-interferon alpha conjugates from loss and degradation during the lyophilization process, as well as degradation during subsequent storage. The formulations of the present invention are suitable for protection of PEG-interferon alpha conjugates from various types of degradation, including, but not limited to loss of biological activity and changes in the degree and/or nature of conjugation. A preferred PEG-interferon alpha conjugate protectable in the formulations of the present invention is an interferon alpha-2b-polyethylene glycol (12,000) conjugate.
Data supplied from the esp@cenet database - l2