Formulation strategies in stabilizing peptides in organic solvents and in dried states

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Formulation strategies in stabilizing peptides in organic solvents and in dried states
Patent Number: US2005009739
Publication date: 2005-01-13
Inventor(s): WANG WEI [US]; WANG YU-CHANG JOHN [US]; MARTIN-MOE SHERYL [US]
Applicant(s):
Requested Patent: US2005009739
Application Number: US20040500680 20040701
Priority Number(s): WO2003US04790 20030214; US20020356915P 20020214; US20040500680 20040701
IPC Classification: A61K38/22
Abstract
The invention relates to stabilized formulations of therapeutically active peptides, particularly PACAP 66. Formulations of the invention include a peptide containing at least one histidine residue, a transition metal salt and an organic solvent. The above formulations may contain peptides that have at least one asparagine residue and are acidified and dried (such as spray-dried or freeze-dried) before formulation preparation. Other formulations of the invention relate to stabilized formulations of PACAP 66 or peptides containing an asparagine residue, which are acidified and dried (such as spray-died or freeze-dried) with or without a transition metal salt.
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