FREEZE DRIED LIPOSOME ENCAPSULATED AMPHIPHILIC DRUG COMPOSITIONS AND A PROCESS FOR THE PREPARATION THEREOF

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12) Patent Application: (11) CA 2253974
ABSTRACT:
A process for the preparation of freeze dried liposome encapsulated amphiphilic drug compositions, which process comprises preparing a liposomal suspension of multilamellar vesicles (MLVs) which encapsulate an amphiphilic drug composition, adding sorbitol to the liposomal suspension and lyophilisation of the suspension.
(72) Inventors (Country): LEGROS, FRANZ (Belgium)
CAMU, FREDERIC (Belgium)
BRASSEUR, ROBERT (Belgium)
CARLINO, SANDRA (Belgium)

(73) Owners (Country): VRIJE UNIVERSITEIT BRUSSEL (Belgium)
(71) Applicants (Country): VRIJE UNIVERSITEIT BRUSSEL (Belgium)
(74) Agent: FETHERSTONHAUGH & CO.
(45) Issued:
(86) PCT Filing Date: May 12, 1997
(87) PCT Publication Date: Nov. 20, 1997
Examination requested: Mar. 26, 2002
(51) International Class (IPC): A61K 9/127
A61K 31/195
A61K 31/44
A61K 31/445
A61K 31/485
Patent Cooperation Treaty (PCT): Yes (85) National Entry: Nov. 9 , 1998
(86) PCT Filing number: PCT/EP1997/002421
(87) International publication number: WO1997/042936
(30) Application priority data: Application No. Country Date
9609779.5 U.K. May 10, 1996
Availability of licence: N/A
Language of filing: English