Crystallized hnf4 gamma ligand binding domain polypeptide and screening methods employing same

/Home/Lyophilization and Protein Formulation Patents/Patent Articles - Lyophilization/Patent Pending - Lyophilization

United States Patent Application 20050131209
Kind Code A1
Davis, Roderick Gerald ; et al. June 16, 2005
Crystallized hnf4 gamma ligand binding domain polypeptide and screening methods employing same
Abstract
A solved three-dimensional crystal structure of an HNF4g ligand binding domain polypeptide is disclosed, along with a crystal form of the HNF4g ligand binding domain. Methods of designing modulators of the biological activity of HNF4g, and other HNF4 ligand binding domain polypeptides are also disclosed.
Inventors: Davis, Roderick Gerald; (Durham, NC) ; Johnson, Robert Lloyd; (Durham, NC) ; Miller, Aaren Bayne; (Durham, NC) ; Way, James M; (Durham, NC) ; Williams, Shawn P; (Durham, NC) ; Willson, Timothy Mark; (Durham, NC) ; Wisely, George Bruce; (Durham, NC) ; Kontz, Ann Miller; (Wilmington, NC)
Correspondence Name and Address: DAVID J LEVY, CORPORATE INTELLECTUAL PROPERTY
GLAXOSMITHKLINE
FIVE MOORE DR., PO BOX 13398
RESEARCH TRIANGLE PARK
NC
27709-3398
US

Serial No.: 470958
Series Code: 10
Filed: June 23, 2004
PCT Filed: January 31, 2002
PCT NO: PCT/US02/02992
U.S. Current Class: 530/350; 702/19
U.S. Class at Publication: 530/350; 702/019
Intern'l Class: C07K 014/72; G06F 019/00; G01N 033/48; G01N 033/50