Control of DNA hybridization by photoswitchable mismatch binding ligands - DNA

Control of DNA hybridization by photoswitchable mismatch binding ligands
2006
Chikara Dohno, Shin-nosuke Uno and Kazuhiko Nakatani
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan
Nucleic Acids Symposium Series 2006
We herein demonstrate that mismatch binding ligands (MBL) can function as a molecular glue which brings two single stranded DNA (ssDNA) together to form the double stranded DNA (dsDNA). Incorporation of a photoisomerizable azobenzene linkage provides further ability of reversibly controlling duplex stability with light.
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