Continuous analyte sensing with magnetic nanoswitches

Continuous analyte sensing with magnetic nanoswitches
Engineering Village 2
2006 Elsevier Inc.
Accession number: 063810118214

Title: Continuous analyte sensing with magnetic nanoswitches

Authors: Sun, Eric Yi; Weissleder, Ralph; Josephson, Lee

Author affiliation: Center for Molecular Imaging Research, Massachusetts General Hospital, Building 149, Charlestown, MA 02129, United States

Serial title: Small

Abbreviated serial title: Small

Volume: v 2

Issue: n 10

Issue date: October 2006

Publication year: 2006

Pages: p 1144-1147

Language: English

ISSN: 1613-6810

Document type: Journal article (JA)

Publisher: Wiley-VCH Verlag, Weinheim, D-69451, Germany

Abstract: The development of implantable sensors to monitor the changing concentration of chemically diverse drugs, metabolites, and biomarkers by using nanotechnology is discussed. Glucose oxidase-based glucose sensors that generate hydrogen peroxide can detect different binding proteins amperometrically. Magnetic relaxation nanoswitches, which is an implantable sensor, could be employed for the continuous monitoring of analytes. The feasibility study of magnetic nanoswitch system with chemically distinct analytes is conducted by examining with glucose (Glu), folic acid (FA), and the influenza hemagglutinin peptide (HA). Light-scattering measurements were obtained to further investigate the interconversion between the initial dispersed nanoparticle state and microaggregated state. The increase and decrease in glucose concentration results in the alteration of the nanoswitch microaggregation state. The experiment establishes the principle of an analyte-mediated equilibrium of nanoswitches.

Abstract type: (Edited abstract)

Number of references: 14

Ei main heading: Nanostructured materials

Ei controlled terms: Switches - Magnetic devices - Drug products - Metabolites - Biomarkers - Nanotechnology - Hydrogen peroxide - Nuclear magnetic resonance

Uncontrolled terms: Analytes - Nanomedicine - Nanoswitches - Magnetic nanoswitches

Ei classification codes: 933.1 Crystalline Solids - 708.4 Magnetic Materials - 461.6 Medicine - 461.2 Biological Materials - 481.1 Geology - 804.2 Inorganic Compounds - 931.2 Physical Properties of Gases, Liquids & Solids

Treatment: Theoretical (THR); Experimental (EXP)

DOI: 10.1002/smll.200600204

Database: Compendex

Compilation and indexing terms, ? 2006 Elsevier Inc. All rights reserved
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