Continuous analyte sensing with magnetic nanoswitches
Continuous analyte sensing with magnetic nanoswitches
Engineering Village 2
2006 Elsevier Inc.
Accession number: 063810118214
Title: Continuous analyte sensing with magnetic nanoswitches
Authors: Sun, Eric Yi; Weissleder, Ralph; Josephson, Lee
Author affiliation: Center for Molecular Imaging Research, Massachusetts General Hospital, Building 149, Charlestown, MA 02129, United States
Serial title: Small
Abbreviated serial title: Small
Volume: v 2
Issue: n 10
Issue date: October 2006
Publication year: 2006
Pages: p 1144-1147
Language: English
ISSN: 1613-6810
Document type: Journal article (JA)
Publisher: Wiley-VCH Verlag, Weinheim, D-69451, Germany
Abstract: The development of implantable sensors to monitor the changing concentration of chemically diverse drugs, metabolites, and biomarkers by using nanotechnology is discussed. Glucose oxidase-based glucose sensors that generate hydrogen peroxide can detect different binding proteins amperometrically. Magnetic relaxation nanoswitches, which is an implantable sensor, could be employed for the continuous monitoring of analytes. The feasibility study of magnetic nanoswitch system with chemically distinct analytes is conducted by examining with glucose (Glu), folic acid (FA), and the influenza hemagglutinin peptide (HA). Light-scattering measurements were obtained to further investigate the interconversion between the initial dispersed nanoparticle state and microaggregated state. The increase and decrease in glucose concentration results in the alteration of the nanoswitch microaggregation state. The experiment establishes the principle of an analyte-mediated equilibrium of nanoswitches.
Abstract type: (Edited abstract)
Number of references: 14
Ei main heading: Nanostructured materials
Ei controlled terms: Switches - Magnetic devices - Drug products - Metabolites - Biomarkers - Nanotechnology - Hydrogen peroxide - Nuclear magnetic resonance
Uncontrolled terms: Analytes - Nanomedicine - Nanoswitches - Magnetic nanoswitches
Ei classification codes: 933.1 Crystalline Solids - 708.4 Magnetic Materials - 461.6 Medicine - 461.2 Biological Materials - 481.1 Geology - 804.2 Inorganic Compounds - 931.2 Physical Properties of Gases, Liquids & Solids
Treatment: Theoretical (THR); Experimental (EXP)
DOI: 10.1002/smll.200600204
Database: Compendex
Compilation and indexing terms, ? 2006 Elsevier Inc. All rights reserved
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