Compositions for treating drug resistance - Patents

Compositions for treating drug resistance

Agent: Morrison & Foerster LLP - San Diego, CA, US
Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew
Class: 424450000 (USPTO), (Intl Class)
#20060216341
09/28/06
Delivery vehicle compositions having stably associated therewith at least one therapeutic agent and at least one drug resistance modulator are useful in achieving a biologic effect to a drug resistance target.
TECHNICAL FIELD
[0002] The invention relates to compositions and methods for delivery of a therapeutic agent and a drug resistance modulator to a drug resistant target. More particularly, the invention concerns delivery vehicle compositions of a size range between 50 and 300 nm which provide combinations of therapeutic agents and drug resistance modulators to a drug resistance target.
DISCLOSURE OF THE INVENTION
[0011] The invention relates to methods for administering a drug resistance modulator and a therapeutic agent or two drug resistance modulators using delivery vehicle compositions that are of a size range between 50 and 300 nm. Encapsulation in delivery vehicles allows the drug resistance modulator and the therapeutic agent to be delivered to a disease site in a coordinated fashion. The pharmacokinetics (PK) of the composition are controlled by the delivery vehicles themselves, such that coordinated delivery is achieved (provided that the PK of the delivery systems are comparable). By administering delivery vehicles that are in a size range of 50-300 nm, the associated agents are delivered to a target site such that a desired therapeutic effect is attained. This may be due to reduced uptake by the reticuloendothelial system (RES) and the mononuclear phagocyte system (MPS) and enhanced stability in the bloodstream. This result can be achieved whether the agents are co-encapsulated in delivery vehicles, or are separately encapsulated in delivery vehicles.
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