Compositions for topical enzymatic debridement

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Compositions for topical enzymatic debridement
Inventor: TRUMBORE MARK W (US); RARIY ROMAN V (US)
Applicant: COLLEGIUM PHARMACEUTICAL INC D
IPC: A61K33/36; A61K33/38; A61K38/46
Publication info: US2005281806
Date: 2005-12-22
Abstract of US2005281806
Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.