Compositions and processes using siRNA, amphipathic compounds and polycations

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Compositions and processes using siRNA, amphipathic compounds and polycations
United States Patent 7,101,995
Lewis , et al.
September 5, 2006
Inventors: Lewis; David L. (Madison, WI), Hagstrom; James E. (Madison, WI), Herweijer; Hans (Madison, WI), Loomis; Aaron G. (Prairie du Sac, WI), Monahan; Sean D. (Madison, WI), Wolff; Jon A. (Madison, WI)
Assignee: Mirus Bio Corporation (Madison, WI)
Appl. No.: 10/157,674
Filed: May 28, 2002
Abstract
Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.