Compositions and methods for stabilizing biological molecules upon lyophilization
Patent Number: US2003124139
Publication date: 2003-07-03
Inventor(s): ESIKOVA IRINA [US]; WOLFE SIDNEY [US]; THOMSON JAMES [US]; HORA MANINDER [US]
Applicant(s):
Requested Patent: US2003124139
Application Number: US20020148559 20021120
Priority Number(s): US20020148559 20021120
IPC Classification: A61K39/00
EC Classification: A61K9/00N10, A61K9/19, A61K39/095, A61K47/18, A61K47/18B, A61K47/26
Equivalents:
Abstract
The present invention is directed to compositions and methods for the preparation of biological molecules, in particular MenC-CRM 197. Biological molecules dissolved in dissolution buffers comprising at least one amorphous excipient and an amorphous buffer exhibit reduced aggregation and proteolytic breakdown.
Data supplied from the esp@cenet database - l2
Votes:40
Comments: 0