Compositions and methods for sirna inhibition of angiogenesis

Compositions and methods for sirna inhibition of angiogenesis
United States Patent 7,148,342
Tolentino , et al.
December 12, 2006
Inventors: Tolentino; Michael J. (Villanova, PA), Reich; Samuel Jotham (Bala Cynwyd, PA)
Assignee: The Trustees of the University of Pennyslvania (Philadelphia, PA)
Appl. No.: 10/294,228
Filed: November 14, 2002
Abstract
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Comments: 0
Votes:15