Compositions and methods for short interfering nucleic acid inhibition of NAv1.8
Compositions and methods for short interfering nucleic acid inhibition of NAv1.8
Publication number: US2006199779
Publication date: 2006-09-07
Inventor: GOREGAOKER SAMEER (US); HUNTER JOHN C (US); PRIESTLEY TONY (US)
Applicant: SCHERING CORP
Classification:
- international: A61K48/00; C07H21/02; A61K48/00; C07H21/00;
- european:
Application number: US20050259588 20051026
Priority number(s): US20050259588 20051026; US20040622484P 20041027
Abstract of US2006199779
The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Na<SUB>v</SUB>1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
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