Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries

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Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
Inventor: GORENSTEIN DAVID G (US); YANG XIANBIN (US)
Applicant: UNIV TEXAS (US)
IPC: C12Q1/68; G01N33/53; G01N33/543
Publication info: US2005123939
Date: 2005-06-09
Abstract of US2005123939
The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.