Alpha-substituted heteroarylalkyl phosphonate derivatives

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United States Patent Application 20050124581
Kind Code A1
Phan, Hieu Trung ; et al. June 9, 2005
Alpha-substituted heteroarylalkyl phosphonate derivatives
Abstract
The present invention relates to novel .alpha.-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
Inventors: Phan, Hieu Trung; (Tannay, CH) ; Nguyen, Lan Mong; (Nyon, CH) ; Azoulay, Raymond; (Geneve, CH) ; Diep, Vinh Van; (Vetraz-Monthoux, FR) ; Niesor, Eric Joseph; (Nyon, CH) ; Bentzen, Craig Leigh; (Bogis-Bossey, CH) ; Ife, Robert John; (Stevenage, Hertfordshire, GB)
Correspondence Name and Address: MCDONNELL BOEHNEN HULBERT & BERGHOFF LLP
300 S. WACKER DRIVE
32ND FLOOR
CHICAGO
IL
60606
US

Serial No.: 504081
Series Code: 10
Filed: January 24, 2005
PCT Filed: February 3, 2003
PCT NO: PCT/US03/03091
U.S. Current Class: 514/79; 514/85; 514/89; 544/232; 544/243; 546/22; 548/112
U.S. Class at Publication: 514/079; 514/089; 514/085; 544/243; 544/232; 546/022; 548/112
Intern'l Class: A61K 031/675