Advances in the development of a novel method to be used in proteomics using gold nanobeads
Advances in the development of a novel method to be used in proteomics using gold nanobeads
Engineering Village 2
? 2006 Elsevier Inc
Accession number: 06269967774
Title: Advances in the development of a novel method to be used in proteomics using gold nanobeads
Authors: Dietrich, Heidelinde R. C.; Young, Ian T.; Garini, Yuval
Author affiliation: Department of Imaging Science and Technology, Quantitative Imaging Group, Delft University of Technology, NL-2628 CJ Delft, Netherlands
Serial title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Abbreviated serial title: Progr. Biomed. Opt. Imaging Proc. SPIE
Volume: v 6092
Monograph title: Ultrasensitive and Single-Molecule Detection Technologies
Publication year: 2006
Pages: p 60920C
Language: English
ISSN: 1605-7422
Document type: Conference article (CA)
Conference name: Ultrasensitive and Single-Molecule Detection Technologies
Conference date: Jan 21-24 2006
Conference location: San Jose, CA, United States
Publisher: International Society for Optical Engineering, Bellingham WA, WA 98227-0010, United States
Abstract: The study of DNA-protein interactions is gaining increased attention due to their importance in cellular processes. Only a well-functioning interaction guaranties that such a process can take place without errors. So far, only a small percentage of these interactions have been unraveled, partially due to their complexity but also due to the fact that there are only a few techniques that permit the study of these interactions. In this report we describe the development of a research tool based on tethered bead motion and Resonance Light Scattering (RLS) from gold beads. This method permits the study of DNA-protein interactions and the screening of proteins binding to a specific DNA sequence.
Number of references: 21
Ei main heading: Proteins
Ei controlled terms: Nanostructured materials - Gold - DNA - Resonance - Light scattering - Error analysis
Uncontrolled terms: Single molecule detection - Resonance light scattering - Molecular interactions - Quantitative microscopy
Ei classification codes: 804.1 Organic Compounds - 933.1 Crystalline Solids - 547.1 Precious Metals - 461.2 Biological Materials - 931.1 Mechanics - 741.1 Light/Optics - 921.6 Numerical Methods
Treatment: Theoretical (THR); Experimental (EXP)
DOI: 10.1117/12.645908
Database: Compendex
Compilation and indexing terms, ? 2006 Elsevier Inc. All rights reserved
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