A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles

A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles
March 2003
Received 15 August 2002; revised 20 December 2002; accepted 20 December 2002. ; Available online 8 February 2003.
Patrick Shahgaldian, , J?r?me Gualbert, Ka?s A?ssa and Anthony W. Coleman
European Journal of Pharmaceutics and Biopharmaceutics
Volume 55, Issue 2
ScienceDirect
Institut de Biologie et Chimie des Prot?ines, Lyon, France
Abstract
In this note, we report a study of cryoprotectant carbohydrate (glucose, fructose, mannose and maltose) effects on the reconstitution of calixarene based solid lipid nanoparticle (SLN) suspensions after freeze-drying, studied by atomic force microscopy and photon correlation spectroscopy. All carbohydrates tested showed excellent cryoprotection and redispersion properties with the calixarene based SLNs.
Author Keywords: Calixarenes; Solid lipid nanoparticles; Carbohydrates; Cryoprotectants; Atomic force microscopy
Corresponding author. Institut de Biologie et Chimie des Prot?ines, CNRS UMR 5086, 7 passage du Vercors, Lyon Cedex 07, F69367, France. Tel.: +33-4-72-72-26-95; fax: +33-4-72-72-26-90
Corresponding author. Institut de Biologie et Chimie des Prot?ines, CNRS UMR 5086, 7 passage du Vercors, Lyon Cedex 07, F69367, France. Tel.: +33-4-72-72-26-95; fax: +33-4-72-72-26-90