A one dose syringe, comprising a freeze-dried protein composition, for administering of a volume less than 0.5 ml - European Patents

Patent number: HK1032920
Publication date: 2005-04-01
Inventor: LIMRELL KARIN; FLORIN-ROBERTSSON EBBA; HOKBY ELVY; NILSSON ULF; STROM ANDERS
Applicant: PHARMACIA & UPJOHN AB (SE)
Classification:
- international: A61M; A61K
- european:
Application number: HK20010103571 20010523
Priority number(s): SE19970004405 19971128; WO1998SE02096 19981119
Abstract not available for HK1032920
Abstract of correspondent: US6152897
The invention relates to a one-dose syringe comprising a first chamber with a freeze-dried composition comprising a protein in an amount of less than 1.4 mg, amino acid and stabilizer where the weight ratio between protein and amino acid versus stabilizer is less than 1.5 and in which the ratio of the weight of the dry component versus the cake volume in the first chamber is above 12 mg/ml, and a second chamber with an aqueous reconstitution solution with an injectable volume of less than 0.5 ml.
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